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We report a patient with fever as the sole manifestation of initial HSR, review the literature and discuss the management of HSR. She tolerated the first 8 cycles without any toxicities except grade 1 peripheral neuropathy and nausea. During 9 th and 10 th infusions, she developed fever to a maximum of During 11 th infusion, she developed grade 3 HSR consisting of symptomatic bronchospasm, hypotension, nausea, vomiting, cough, and fever.
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FOLFIRINOX (or FOLFOXIRI) - Macmillan Cancer Support

Department of Internal Medicine, St. Oxaliplatin is a third-generation platinum compound that is used as a single agent and in combination with fluorouracil 5-FU to treat colorectal and gastric carcinoma. The patients treated with oxaliplatin may develop hypersensitivity and idiosyncratic reactions, although these complications are known to be rare. We report here on two patients who suffered with metastatic colorectal cancer and who underwent palliative combination chemotherapy with oxaliplatin; they then developed hypersensitivity reactions to oxaliplatin. The first case had an anaphylatic reaction immediately after the beginning of the 7 th to 8 th cycle infusion of oxaliplatin.
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Oxaliplatin (Eloxatin)

Anticancer drugs drugs used to treat cancer can sometimes cause serious problems. It is important to get medical help immediately if you become unwell. During your treatment immediately tell the doctor or nurse looking after you if you get any of the following problems:. Sometimes a treatment may be started at a lower dose or the dose needs to be changed during treatment.
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It may sometimes be used to treat other cancers. Your doctor will talk to you about this treatment and its possible side effects before you agree consent to have treatment. They are named after the initials of the drugs used for treatment. The drugs are:.
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